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Keep an eye on Closely (one)pentobarbital will lower the level or outcome of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead into a reduce in fentanyl plasma concentrations, not enough efficacy or, quite possibly, improveme